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Reopen Madeleine case, police urge

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Scotland Yard has urged Portuguese authorities to reopen the search for Madeleine McCann as detectives said there are 195 potential leads to finding her alive. The detective leading the Metropolitan Police review said the case can still be solved before officers released a picture of what she might now look like as a nine-year-old. Detective Chief Inspector Andy Redwood said he believes her disappearance was a stranger abduction, as he said there are 195 "investigative opportunities". Police refused to say what evidence they had uncovered to suggest Madeleine is alive. Mr Redwood confirmed that his team of more than 30 officers involved in the case had been out to Portugal seven times, including a visit to the family's holiday flat in Praia da Luz. It will be five years ago next week since the three-year-old went missing as her parents, Kate and Gerry McCann, dined with friends nearby. A spokesman for the McCanns said the family was pleased with the image. Mr Redwood said his 37 officers had dealt with 40,000 pieces of information but the "primacy still sits in Portugal" in the attempt to find her. Commander Simon Foy said: "Most significantly, the message we want to bring to you is that, on the evidence, there is a possibility that she is alive and we desperately need your help today to appeal directly to the public for information to support our investigation." Mr Redwood said "evidence that she is alive stems from the forensic view of the timeline" that there was the opportunity for her to be taken. Investigations show "there do appear to be gaps", he added. Detectives in Portugal are also understood to want the case reopened but must gain judicial approval via the courts.

Insecure websites to be named and shamed after checks

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Companies that do not do enough to keep their websites secure are to be named and shamed to help improve security. The list of good and bad sites will be published regularly by the non-profit Trustworthy Internet Movement (TIM). A survey carried out to launch the group found that more than 52% of sites tested were using versions of security protocols known to be compromised. The group will test websites to see how well they have implemented basic security software. Security fundamentals The group has been set up by security experts and entrepreneurs frustrated by the slow pace of improvements in online safety. "We want to stimulate some initiatives and get something done," said TIM's founder Philippe Courtot, serial entrepreneur and chief executive of security firm Qualys. He has bankrolled the group with his own money. TIM has initially focused on a widely used technology known as the Secure Sockets Layer (SSL). Experts recruited to help with the initiative include SSL's inventor Dr Taher Elgamal; "white hat" hacker Moxie Marlinspike who has written extensively about attacking the protocol; and Michael Barrett, chief security officer at Paypal. Continue reading the main story “ Start Quote Everyone is now going to be able to see who has a good grade and who has a bad grade” Philippe Courtot Many websites use SSL to encrypt communications between them and their users. It is used to protect credit card numbers and other valuable data as it travels across the web. "SSL is one of the fundamental parts of the internet," said Mr Courtot. "It's what makes it trustworthy and right now it's not as secure as you think." Compromised certificates TIM plans a two-pronged attack on SSL. The first part would be to run automated tools against websites to test how well they had implemented SSL, said Mr Courtot. "We'll be making it public," he added. "Everyone is now going to be able to see who has a good grade and who has a bad grade." Early tests suggest that about 52% of sites checked ran a version of SSL known to be compromised. Companies who have done a bad job will be encouraged to improve and upgrade their implementations so it gets safer to use those sites. The second part of the initiative concerns the running of the bodies, known as certificate authorities, which guarantee that a website is what it claims to be. TIM said it would work with governments, industry bodies and companies to check that CAs are well run and had not been compromised. "It's a much more complex problem," said Mr Courtot. In 2011, two certificate authorities, DigiNotar and GlobalSign were found to have been compromised. In some cases this meant attackers eavesdropped on what should have been a secure communications channel. Steve Durbin, global vice president of the Information Security Forum which represents security specialists working in large corporations, said many of its members took responsibility for making sure sites were secure. "You cannot just say 'buyer beware'," he said. "That's not good enough anymore. They have a real a duty of care." He said corporations were also increasingly conscious of their reputation for providing safe and secure services to customers. Data breaches, hack attacks and poor security were all likely to hit share prices and could mean they lose customers, he noted.

Anti-depressants likely do more harm than good, study suggests

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Commonly prescribed anti-depressants appear to be doing patients more harm than good, say researchers who have published a paper examining the impact of the medications on the entire body. See Also: Health & Medicine Pharmacology Birth Defects Mental Health Research Mind & Brain Depression Disorders and Syndromes Psychiatry Reference COX-2 inhibitor Psychoactive drug Seasonal affective disorder Anti-obesity drug "We need to be much more cautious about the widespread use of these drugs," says Paul Andrews, an evolutionary biologist at McMaster University and lead author of the article, published recently in the online journal Frontiers in Psychology. "It's important because millions of people are prescribed anti-depressants each year, and the conventional wisdom about these drugs is that they're safe and effective." Andrews and his colleagues examined previous patient studies into the effects of anti-depressants and determined that the benefits of most anti-depressants, even taken at their best, compare poorly to the risks, which include premature death in elderly patients. Anti-depressants are designed to relieve the symptoms of depression by increasing the levels of serotonin in the brain, where it regulates mood. The vast majority of serotonin that the body produces, though, is used for other purposes, including digestion, forming blood clots at wound sites, reproduction and development. What the researchers found is that anti-depressants have negative health effects on all processes normally regulated by serotonin. The findings include these elevated risks: developmental problems in infants problems with sexual stimulation and function and sperm development in adults digestive problems such as diarrhea, constipation, indigestion and bloating abnormal bleeding and stroke in the elderly The authors reviewed three recent studies showing that elderly anti-depressant users are more likely to die than non-users, even after taking other important variables into account. The higher death rates indicate that the overall effect of these drugs on the body is more harmful than beneficial. "Serotonin is an ancient chemical. It's intimately regulating many different processes, and when you interfere with these things you can expect, from an evolutionary perspective, that it's going to cause some harm," Andrews says. Millions of people are prescribed anti-depressants every year, and while the conclusions may seem surprising, Andrews says much of the evidence has long been apparent and available. "The thing that's been missing in the debates about anti-depressants is an overall assessment of all these negative effects relative to their potential beneficial effects," he says. "Most of this evidence has been out there for years and nobody has been looking at this basic issue." In previous research, Andrews and his colleagues had questioned the effectiveness of anti-depressants even for their prescribed function, finding that patients were more likely to suffer relapse after going off their medications as their brains worked to re-establish equilibrium. With even the intended function of anti-depressants in question, Andrews says it is important to look critically at their continuing use. "It could change the way we think about such major pharmaceutical drugs," he says. "You've got a minimal benefit, a laundry list of negative effects -- some small, some rare and some not so rare. The issue is: does the list of negative effects outweigh the minimal benefit?"

Dengue Fever Asian Mosquito Could Invade UK

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Asian Tiger Mosquito

The mosquito can carry dengue and chikungunya viruses

 

A mosquito that spreads tropical diseases including dengue fever may be poised to invade the UK because of climate change.

The Asian tiger mosquito has already been reported in France and Belgium and could be migrating north as winters become warmer and wetter.

Scientists have urged "wide surveillance" for the biting insect across countries of central and northern Europe, including the UK.

The mosquito can carry dengue and chikungunya viruses, both of which cause high fevers. The infections usually occur in tropical regions of Africa, Asia and South America.

Scientists led by Dr Samantha Martin, from the University of Liverpool, used climate models to predict how changing conditions might affect Asian tiger mosquito distribution.

They wrote in the Journal of the Royal Society Interface: "Mosquito climate suitability has significantly increased over the southern UK, northern France, the Benelux, parts of Germany, Italy, Sicily and the Balkan countries."

The research shows that parts of the UK could become hot-spots of Asian tiger mosquito activity between 2030 and 2050.

The mosquito has been introduced into Europe from Asia via goods shipments, mainly used tyres and bamboo.

Climate change is now shifting conditions suitable for the insect from southern Europe to central north-western areas.

The mosquito could survive in water butts and vases, and may find winter protection in greenhouses, said the researchers.

Opiates Killed 8 Americans In Afghanistan, Army Records Show

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Eight American soldiers died of overdoses involving heroin, morphine or other opiates during deployments in Afghanistan in 2010 and 2011, according to U.S. Army investigative reports. The overdoses were revealed in documents detailing how the Army investigated a total of 56 soldiers, including the eight who fell victim to overdoses, on suspicion of possessing, using or distributing heroin and other opiates. At the same time, heroin use apparently is on the rise in the Army overall, as military statistics show that the number of soldiers testing positive for heroin has grown from 10 instances in fiscal year 2002 to 116 in fiscal year 2010. Army officials didn't respond to repeated requests for comment on Saturday. But records from the service's Criminal Investigation Command, obtained by the conservative legal group Judicial Watch, provided glimpses into how soldiers bought drugs from Afghan juveniles, an Afghan interpreter and in one case, an employee of a Defense Department contractor, who was eventually fired. The drug use is occurring in a country that is estimated to supply more than 90% of the world's opium, and the Taliban insurgency is believed to be stockpiling the drug to finance their activities, according to a 2009 U.N. study. While the records show some soldiers using heroin, much of the opiate abuse by U.S. soldiers in Afghanistan involves prescription drugs such Percocet, the Army documents show. Judicial Watch obtained the documents under the Freedom of Information of Act and provided them to CNN. Spokesman Col. Gary Kolb of the International Security Assistance Force, the NATO-led command in Afghanistan, verified the documents to CNN on Saturday. One fatal overdose occurred in June 2010 at Forward Operating Base Blessing, after a soldier asked another soldier to buy black tar opium from a local Afghan outside the base's entry control point. The first soldier died after consuming the opium like chewing tobacco and smoking pieces of it in a cigarette, the documents show. The reports even show soldier lingo for the drug -- calling it "Afghani dip" in one case where three soldiers were accused of using the opiate, the Army investigative reports show. The United States has 89,000 troops in Afghanistan. The U.S. death toll since the September 11, 2001, attacks that triggered the war has risen to more than 1,850, including 82 this year, according to the U.S. Department of Defense and U.S. Central Command. Tom Fitton, president of Judicial Watch, said his group was interested in soldiers' drug use partly because the risk was present during the Vietnam War. "You never want to see news of soldiers dying of drug use in Afghanistan," Fitton said. "Our concern is, will the military treat this as the problem that it is, and are the families of the soldiers aware of the added risk in this drug-infested country? "There is a dotted line between the uses. Prescription abuse can easily veer into heroin drug use," Fitton added. "Afghanistan is the capital of this opiate production and the temptation is great there and the opportunity for drug use all the more." The group is concerned that "there hasn't been enough public discussion, and we would encourage the leadership to discuss or talk about this issue more openly," Fitton said. In one case, a soldier bought heroin and the anti-anxiety drug Xanax from five "local national juveniles at multiple locations on Camp Phoenix, Afghanistan, and consumed them," one report states. Soldiers also distributed heroin, Percocet and other drugs among themselves, according to the reports. Another soldier fatally overdosed in December 2010 after taking several drugs, including morphine and codeine, though the drugs were not prescribed for him, the Army documents show. One female soldier broke into the Brigade Medical Supply Office at Forward Operating Base Shank and stole expired prescription narcotics including morphine, Percocet, Valium, fentanyl and lorazepam, the documents show. The investigative reports show soldiers using other drugs, including steroids and marijuana, and even hashish that was sold to U.S. servicemen by the Afghan National Army and Afghan National Police personnel, the reports state.

exploding the common myths about which foods are good for us

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Myth: Salt in your diet causes high blood pressure

In the 1940s, Walter Kempner, a researcher at Duke University, North Carolina, became famous for using salt restriction to treat people with high blood pressure. Later, studies confirmed that reducing salt could help reduce hypertension. But you don't have to avoid salt entirely, says Sara Stanner, of the Nutrition Society. "Adults need a small amount of sodium in their diet to maintain the body's fluid balance."

Average salt intakes have come down in recent years, mainly due to product reformulation. But it's still the case that many of us consume too much salt – around 9g a day instead of the maximum recommended dose of 6g per day – around 75 per cent of which is in processed foods such as soups, sauces, sandwiches and processed meat.

"People often think it's really bad to add salt into cooking or on to your plate, but that forms no more than 10 per cent of your total intake," says Stanner. "So you can get people who never have salt at their table, but have a very high salt intake, while others put salt on most meals, but have a lower intake."

Myth: Carbohydrates are bad for you

"Carbohydrate-rich foods are an ideal source of energy. They can also provide a lot of fibre and nutrients," says Sara Stanner. "Potatoes, for instance, are one of the best sources of vitamin C, yet potato consumption in the UK has fallen considerably."

One of the main reasons carbohydrates have fallen out of favour is that they are perceived to be fattening. "Foods high in carbohydrates have had a rough time in the past few years, thanks to the success of low-carb diets, such as the Atkins diet," explains Juliette Kellow.

"But there's no proof that carb-rich foods are more likely to make us gain weight than any other food. Ultimately, it's an excess of calories that makes us pile on the pounds – and it really doesn't matter where those extra calories come from. More often than not, it's the fat we add to carbs that boosts the calorie content, such as butter on toast, creamy sauces with pasta and frying potatoes to make chips."

Myth: Dairy products are fattening and unhealthy

In a study by the Curtin University of Technology in Perth, Australia, slimmers on low- calorie diets which included cheese, yoghurt and milk lost more weight than those on low-dairy diets. Those on the diet including dairy also had the least stomach fat, lower blood pressure and a significantly better chance of avoiding heart disease and diabetes.

Dairy products are packed with essential nutrients that help keep us healthy, says Juliette Kellow. "As well as being good sources of protein, zinc and some B vitamins, dairy products are packed with calcium, a mineral that helps to build strong, healthy bones – and the stronger the bones are, the less likely you'll be to suffer from osteoporosis in later life."

There are loads of low-fat versions of dairy, such as skimmed or semi-skimmed milk, low-fat yoghurts and reduced-fat cheeses, she says – and low-fat versions don't mean less calcium. "Skimmed and semi-skimmed milk actually contain slightly more calcium than full-fat milk."

Myth: Red meat is bad for you

Publishing what it called "the most authoritative ever report of bowel cancer risk" last year, the World Cancer Research Fund recommended that people limit their intake of red meat to 500g a week, or just over a pound in weight. The net result of such studies is always the same – people panic.

But 500g is roughly the equivalent of five or six medium portions of roast beef, lamb or pork. "Red meat is a valuable source of minerals and vitamins, particularly iron, and we know that large numbers of women have such low intakes of this nutrient that they're at risk of anaemia. There's no need for people to think, 'I should be eating fish' when they have a steak,' provided they eat it in moderation," says Sarah Schenker.

Another myth about red meat is that it's high in fat, says Juliette Kellow, dietitian and advisor to Weight Loss Resources. "Thanks to modern breeding programmes and new trimming techniques, red meat is now leaner than ever.

Processed meat of all kinds, however, should be avoided.

Myth: Fresh is always better than frozen

Frozen fruit and vegetables can be more healthy than fresh. "Research shows that freezing vegetables such as peas as soon as they're picked – when they are at their nutritional peak – means they retain higher levels of vitamins, particularly vitamin C," says Sarah Schenker. "Once frozen, the deterioration process stops, locking in goodness. The fresh variety often travel long distances and sit on grocery shelves and along the way, heat, air, water and time can lead to a significant loss of nutrients."

Frozen or canned fruits and vegetables can also be as nutritious as fresh ones, if not more so. Again, they are often packaged within hours of being picked, retaining their nutritional value. "Always check salt and sugar levels though by comparing labels," says Sarah Schenker, of the British Dietitic Association. Even dried fruit can be healthier than fresh. "When you eat dried fruit you usually eat more than the fresh equivalent – for instance six dried apricots instead of three fresh ones. This is more calorific but you get a bigger amount of nutrients," says Schenker.

Myth: Soy eases menopausal problems

For years, the fact that Asian women have fewer menopausal symptoms has been attributed to high levels of soy in their diet. Soy products such as tofu contain natural plant oestrogens and there have been increasing claims that these might help women going through the menopause whose own oestrogen levels are dwindling.

But a University of Miami study has found that soy does nothing to abate hot flushes and bone-density loss. In fact, the women given soy appeared to experience more hot flushes than those given a placebo.

Experts including Dr Malcolm Whitehead, a menopause expert at King's College Hospital in London, aren't surprised. "In my clinical experience, women say this doesn't work for them," he says, adding that HRT is a safe and effective treatment for most women.

Others point to previous studies showing that soy can work, but the British Dietetic Association's Sarah Schenker, says, "This research has always been weak. People got excited about those early small studies, but the more research that was done, the more doubts appeared."

Myth: Brown bread is better for you than white

A darker loaf of bread does not necessarily mean it's made with whole grains – it could simply contain caramel colouring or such a small amount of whole wheat that its nutritional benefits are no different to white bread. "The real health benefits come from eating wholemeal bread instead of white," says Sarah Schenker.

Wholemeal is made from flour containing all the goodness of wheat grains. The outer husk has not been removed, so the resulting bread is much richer in fibre, protein and vitamins B1, B2, niacin, B6, folic acid and biotin. Brown bread, in contrast, is made from finely milled wheat, from which the bran has been extracted.

Look for the words "whole grain" or "100% whole wheat" on packaging and ensure the first ingredient listed is whole wheat, oats, whole rye, whole grain corn, barley, quinoa, buckwheat or brown rice. Seeded bread is even better, since it contains even more vitamins, minerals and healthy fats.

Myth: Everyone needs a lot of protein

Protein is essential for growth and development, but experts agree that most people eat far too much of it. "The Department of Health recommends that protein should make up around 10-15 per cent of your daily diet – that's around 55g for men and 45g for women," dietitian Azmina Govindji says. "Yet, according to the British Nutrition Foundation, men are probably munching their way through an average of 88g and women around 64g."

So what's fuelling this notion that we need so much? "Some diets, such as the Atkins diet, advocate speedy weight loss on cutting the carbs and piling on the proteins", Govindji says.

Another contributory factor is that in the past, it was believed nobody could eat too much protein. In the early 1900s, people were told to eat well over 100g a day and in the 1950s, health-conscious people were encouraged to boost their protein intake. But high protein can put a strain on liver and kidneys and other bodily systems.

Cause of Brain Freeze Revealed

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Most people have likely experienced brain freeze — the debilitating, instantaneous pain in the temples after eating something frozen — but researchers didn't really understand what causes it, until now. Previous studies have found that migraine sufferers are actually more likely to get brain freeze than people who don't get migraines. Because of this, the researchers thought the two might share some kind of common mechanism or cause, so they decided to use brain freeze to study migraines. Headaches like migraines are difficult to study, because they are unpredictable. Researchers aren't able to monitor a whole one from start to finish in the lab. They can give drugs to induce migraines, but those can also have side effects that interfere with the results. Brain freeze can quickly and easily be used to start a headache in the lab, and it also ends quickly, which makes monitoring the entire event easy. The researchers brought on brain freeze in the lab by having 13 healthy volunteers sip ice water through a straw right up against the roof of their mouth. The volunteers raised their hands when they felt the familiar brain freeze come on, and raised them again once it disappeared. The researchers monitored the blood flow through their brains using an ultrasoundlike process on the skull. They saw that increased blood flow to the brain through a blood vessel called the anterior cerebral artery, which is located in the middle of the brain behind the eyes. This increase in flow and resulting increase in size in this artery brought on the pain associated with brain freeze. [Top 10 Mysteries of the Mind] When the artery constricts, reining in the response to this increased flow, the pain disappears. The dilation, then quick constriction, of this blood vessel may be a type of self-defense for the brain, the researchers suggested. "The brain is one of the relatively important organs in the body, and it needs to be working all the time," study researcher Jorge Serrador, of Harvard Medical School, said in a statement. "It's fairly sensitive to temperature, so vasodilation [the widening of the blood vessels] might be moving warm blood inside tissue to make sure the brain stays warm." This influx of blood can't be cleared as quickly as it is coming in during the brain freeze, so it could raise the pressure inside the skull and induce pain that way. As the pressure and temperature in the brain rise, the blood vessel constricts, reducing pressure in the brain before it reaches dangerous levels. If other headaches work in the same way, drugs that stop these blood vessels from opening up, or that could make this blood vessel constrict could help treat them, the researchers say. [Big Headaches: Facts on Migraines] The work was presented during a poster session Sunday (April 22) afternoon at the Experimental Biology 2012 meeting in San Diego.

Soda consumption increases overall stroke risk

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Researchers from Cleveland Clinic's Wellness Institute and Harvard University have found that greater consumption of sugar-sweetened and low-calorie sodas is associated with a higher risk of stroke. Conversely, consumption of caffeinated or decaffeinated coffee was associated with a lower risk. See Also: Health & Medicine Heart Disease Stroke Prevention Diet and Weight Loss Mind & Brain Stroke Caregiving Gender Difference Living Well Reference High fructose corn syrup Blood sugar Soft drink Multi-infarct dementia The study -- recently published in the American Journal of Clinical Nutrition -- is the first to examine soda's affect on stroke risk. Previous research has linked sugar-sweetened beverage consumption with weight gain, diabetes, high blood pressure, high cholesterol, gout and coronary artery disease. "Soda remains the largest source of added sugar in the diet," said Adam Bernstein, MD, ScD, study author and Research Director at Cleveland Clinic's Wellness Institute. "What we're beginning to understand is that regular intake of these beverages sets off a chain reaction in the body that can potentially lead to many diseases -- including stroke." The research analyzed soda consumption among 43,371 men who participated in the Health Professionals Follow-Up Study between 1986 and 2008, and 84,085 women who participated in the Nurses' Health Study between 1980 and 2008. During that time, 2,938 strokes were documented in women while 1,416 strokes were documented in men. In sugar-sweetened sodas, the sugar load may lead to rapid increases in blood glucose and insulin which, over time, may lead to glucose intolerance, insulin resistance, and inflammation. These physiologic changes influence atherosclerosis, plaque stability and thrombosis -- all of which are risk factors of ischemic stroke. This risk for stroke appears higher in women than in men. In comparison, coffee contains chlorogenic acids, lignans and magnesium, all of which act as antioxidants and may reduce stroke risk. When compared with one serving of sugar-sweetened soda, one serving of decaffeinated coffee was associated with a 10 percent lower risk of stroke. In addition, study findings show that men and women who consumed more than one serving of sugar-sweetened soda per day had higher rates of high blood pressure and high blood cholesterol and lower physical activity rates. Those who drank soda more frequently were also more likely to eat red meat and whole-fat dairy products. Men and women who consumed low-calorie soda had a higher incidence of chronic disease and a higher body mass index (BMI). The investigators controlled for these other factors in their analysis to determine the independent association of soda consumption on stroke risk. "According to research from the USDA, sugar-sweetened beverage consumption has increased dramatically in the United States over the past three decades, and it's affecting our health," said Dr. Bernstein. "These findings reiterate the importance of encouraging individuals to substitute alternate beverages for soda."

What cannabis actually does to your brain

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Archaeologists recently found a 2,700-year-old pot stash, so we know humans have been smoking weed for thousands of years. But it was only about 20 years ago that neuroscientists began to understand how it affects our brains.

Scientists have known for a while that the active ingredient in cannabis was a chemical called delta-9-tetrahydrocannabinol, or THC for short. Ingesting or smoking THC has a wide range of effects, from the psychoactive "getting high" to the physiological relief of pain and swelling. It also acts as both a stimulant and depressant. How could one substance do all that?

What cannabis actually does to your brainMeet the cannabinoid receptor

In the 1980s and 90s, researchers identified cannabinoid receptors, long, ropy proteins that weave themselves into the surfaces of our cells and process THC. They also process other chemicals, many of them naturally occurring in our bodies. Once we'd discovered these receptors, we knew exactly where THC was being processed in our bodies and brains, as well as what physical systems it was affecting. Scattered throughout the body, cannabinoid receptors come in two varieties, called CB1 and CB2 - most of your CB1 receptors are in your brain, and are responsible for that "high" feeling when you smoke pot. CB2 receptors, often associated with the immune system, are found all over the body. THC interacts with both, which is why the drug gives you the giggles and also (when interacting with the immune system) reduces swelling and pain.

 

Cannabinoid receptors evolved in sea squirts about 500 million years ago; humans and many other creatures inherited ours from a distant ancestor we share with these simple sea creatures. THC binds to receptors in animals as well as humans, with similar effects.

Tasty, tasty, tasty

Cannabis notoriously makes people hungry - even cancer patients who had lost all desire to eat.One study showed that cancer patients who thought food smelled and tasted awful suddenly regained an ability to appreciate food odors after ingesting a THC compound. There are CB1 receptors in your hypothalamus, a part of your brain known to regulate appetite, and your body's own cannabinoids usually send the "I'm hungry" message to them. But when you ingest THC, you artificially boost the amount of cannabinoids sending that message to your hypothalamus, which is why you get the munchies.

Understanding this process has actually led to a new body of research into safe diet drugs that would block those cannabinoid receptors. That way, your hypothalamus wouldn't receive signals from your body telling it to eat, and would reduce hunger cravings in dieters.

What you're forgetting

What's happening in your brain when smoking pot makes you forget what you're saying in the middle of saying it? According to the book Marijuana and Medicine (National Academies Press):

One of the primary effects of marijuana in humans is disruption of short-term memory. That is consistent with the abundance of CB1 receptors in the hippocampus, the brain region most closely associated with memory. The effects of THC resemble a temporary hippocampal lesion.

That's right - smoking a joint creates the effect of temporary brain damage.

What happens is that THC shuts down a lot of the normal neuroprocessing that goes on in your hippocampus, slowing down the memory process. So memories while stoned are often jumpy, as if parts are missing. That's because parts literally are missing: Basically you are saving a lot less information to your memory. It's not that you've quickly forgotten what's happened. You never remembered it at all.

What cannabis actually does to your brainA bit of the old timey wimey

Cannabis also distorts your sense of time. THC affects your brain's dopamine system, creating a stimulant effect. People who are stoned often report feeling excited, anxious, or energetic as a result. Like other stimulants, this affects people's sense of time. Things seem to pass quickly because the brain's clock is sped up. At the same time, as we discussed earlier (if you can remember), the drug slows down your ability to remember things. That's because it interferes with the brain's acetylcholine system, which is part of what helps you store those memories in your hippocampus. You can see that system's pathway through the brain in red in the illustration at left.

In an article io9 published last year about the neuroscience of time, we noted:

The interesting thing about smoking pot is that marijuana is one of those rare drugs that seems to interact with both the dopamine and the acetylcholine system, speeding up the former and slowing down the latter. That's why when you get stoned, your heart races but your memory sucks.

It's almost as if time is speeding up and slowing down at the same time.

Addiction and medicine

Some experts call cannabis a public health menace that's addictive and destroys lives by robbing people of ambition. Other experts call it a cure for everything from insomnia to glaucoma, and advocate its use as a medicine. The former want it to be illegal; the latter want it prescribed by doctors. Still other groups think it should be treated like other intoxicants such as alcohol and coffee - bad if you become dependent on it, but useful and just plain fun in other situations.

What's the truth? Scientists have proven that cannabis does have medical usefulness, and the more we learn the more intriguing these discoveries become. Since the early 1980s, medical researchers have published about how cannabis relieves pressure in the eye, thus easing the symptoms of glaucoma, a disease that causes blindness. THC is also "neuroprotective," meaning in essence that it prevents brain damage. Some studies have suggested that cannabis could mitigate the effects of Alzheimer's for this reason.

At the same time, we know that THC interferes with memory, and it's still uncertain what kinds of long-term effects the drug could have on memory functioning. No one has been able to prove definitively that it does or does not erode memory strength over time. Obviously, smoking it could cause lung damage. And, like the legal intoxicant alcohol, cannabis can become addictive.

Should cannabis be illegal, while alcohol flows? Unfortunately that's not the kind of question that science can answer. Let's leave the moral questions to courts, policymakers and shamans. I'll be off to the side, smoking a joint, thinking about my acetylcholine system and the many uses of the hippocampus.

Phone data shows romance 'driven by women'

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A study of mobile phone calls suggests that women call their spouse more than any other person. That changes as their daughters become old enough to have children, after which they become the most important person in their lives. The study has been published in the journal Scientific Reports. It also shows that men call their spouse most often for the first seven years of their relationship. They then shift their focus to other friends. The results come from an analysis of the texts of mobile phone calls of three million people. According to the study's co-author, Professor Robin Dunbar of Oxford University, UK, the investigation shows that pair-bonding is much more important to women than men. "It's the first really strong evidence that romantic relationships are driven by women," he told BBC News. "It's they who make the decision and once they have made their mind up, they just go for the poor bloke until he keels over and gives in!" But the data shows that women start to switch the preference of their best friend from about the mid-30s, and by the age of 45 a woman of a generation younger becomes the "new best friend", according to Professor Dunbar. Continue reading the main story “ Start Quote Human societies are moving back to a matriarchy” Prof Robin Dunbar Oxford University "What seems to happen is that women push the 'old man' out to become their second best friend, and he gets called much less often and all her attention is focussed on her daughters just at the point at which you are likely to see grandchildren arriving," he says. Prof Dunbar also claims that the findings suggest that human societies are moving away from a patriarchy back to a matriarchy. The aim of the project was to find out how close, intimate relationships vary over a lifetime. This kind of anthropological study is normally very difficult to do because it is hard for researchers to get such a big picture of people's lives. But by looking at an at an extremely large mobile phone database, they were able to track these changes extremely accurately. They had access to the age and sex of the callers, who between them made three billion calls and half a billion texts over a period of seven months. Intensely focussed The team wanted to find out how the gender preference of best friends, as defined by the frequency of the calling, changed over the course of a lifetime and differed between men and women. They found that men tend to choose a woman the same age as themselves - which the researchers presumed to be their girlfriend or wife - as a best friend much later in life than women do, and for a much shorter time. This occurs when they are in their early-30s, possibly during courtship, and stops after seven years or so. Women, however, choose a man of a similar age to be their best friend from the age of 20. He remains for about 15 years, after which time he's replaced by a daughter. The pendulum between the two sexes is swinging back towards women, says Prof Dunbar The researchers say that a woman's social world is intensely focussed a on one individual and will shift as a result of reproductive interests from being the mate to children and grandchildren. According to Prof Dunbar, the data suggests that "at root the important relationships are those between women and not those between men". "Men's relationships are too casual. They often function at a high level in a political sense, of course; but at the end of the day, the structure of society is driven by women, which is exactly what we see in primates," he explains. Many anthropologists argue that most human societies are patriarchal on the basis that in most communities men stay where they are born whereas the wives move. But Professor Dunbar and his colleagues are arguing that this only occurs in agriculturally based societies. "If you look at hunter-gatherers and you look at modern humans in modern post-industrial societies, we are much more matriarchal. It's almost as if the pendulum between the two sexes, power-wise, is swinging (back) as we move away from agriculture toward a knowledge-based economy," he says.

Secret Service scandal sheds light on sex tourism in Latin America

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Type in "sex tourism" and "Brazil" in Google, and the first site that comes up is not a news report or academic study, but advice on going rates and how to hire prostitutes. But ahead of the 2014 World Cup and 2016 Olympics, officials are starting to clamp down on the country's image as a haven for sex tourism. Brazil's Tourism Ministry recently said it identified more than 2,000 sites advertising the South American giant's sex industry, many of them hosted in the US. To counter the reputation, the tourism ministry has stepped up efforts to advertise Brazil's natural beauties like beaches and the Amazon, instead of bodies for sale. And they have circulated information reminding visitors that sexual exploitation of minors is a crime.  Brazil's preventive efforts seem more crucial than ever after the scandal in Cartagena, Colombia, during the Sixth Summit of the Americas last weekend. Some 11 US Secret Service agents were sent home for allegedly hiring prostitutes in the steamy colonial city, also a major destination for sex tourism.  “Large events create an obvious clientele and traffickers recognize an opportunity to make money,” says Heather Smith-Cannoy, who teaches international relations at Lewis & Clark College in Portland, Oregon. “I think that in many places around the world there is a 'boys will be boys' attitude about the patronizing of prostitutes," Ms. Smith-Cannoy says. But when considering the combination of large profits for traffickers, and pimps or hustlers, and a relaxed cultural attitude about visiting prostitutes "we can begin to understand both the supply and the demand side of this industry,” says Smith-Cannoy. The trafficking–tourism link Sex “tourism" is nothing new. By some accounts it dates back to the 15th century, with Columbus's arrival to the Americas. As the middle class grew in industrialized nations, and the opportunities to travel with it, the formal industry was developed.  Prostitution is tolerated to varying degrees in Latin America, but it is the human trafficking associated with sex tourism, especially that of minors, that alarms officials most. (The case of Cartagena did not involve minors.) According to the Coalition Against Trafficking of Women and Girls in Latin America and the Caribbean (CATW-LAC), 500,000 women and girls from Latin America and the Caribbean are sexually exploited each year. Not all prostitution involves sex trafficking, a multibillion dollar industry, but the nongovernmental organization World Vision estimates that up to a quarter of women in prostitution have been trafficked.  At the same time, the majority of human trafficking victims — 79 percent — are brought into the sex trade, according to the United Nations. Countries in Asia, notably Thailand, have long been at the center of the problem, but Latin America is starting to play a larger role. “While most trafficking victims still appear to originate from South and Southeast Asia or the former Soviet Union, human trafficking is also a growing problem in Latin America,” writes Clare Ribando Seelke in a 2012 Congressional Research Service report. Poverty, displacement from rural areas, and increased demand for prostitution all play a role in the growth of sexual exploitation, says Humberto Rodriguez, the communication officer of Fundacion Renacer, a Colombia-based group that combats the sexual exploitation of youths in the country. Anywhere the tourism industry grows, he says, so does the opportunity for sexual tourism. 'Not enough is being done' Within sex tourism, the exploitation of children is the biggest concern.  According to the US State Department 2011 report on the trafficking of persons, Brazil, Costa Rica, the Dominican Republic, and Nicaragua all have significant child sex tourist industries. Colombia, it says, is also “a destination for foreign child sex tourists from the United States and Europe, particularly to coastal cities such as Cartagena and Barranquilla.” Countries around the globe have addressed the problem of human trafficking in general since the UN Protocol to Prevent, Suppress, and Punish Trafficking in Persons, Especially Women and Children, was adopted in 2000, but many say not enough is being done. The US State Department assesses efforts around the globe to combat human trafficking. In 2010, 80 percent of countries in South America were placed on the Tier 2 list, which means they were not fully complying with the US Trafficking Victims Protection Act, while 60 percent of countries in Central America and the Caribbean were on the Tier 2 Watch List. Cuba fell to the lowest level of cooperation, Tier 3. The State Department says that prostitution of children over 16 is legal in Cuba, leaving those over the legal age vulnerable to commercial sexual exploitation. Venezuela fell to Tier 3 in the 2011 report. Colombia sits on the Tier 1 list, and while the case of the US Secret Service agents does not fall into Fundacion Renacer's work — as it did not involve children — Mr. Rodriguez says the case may not have generated so much attention in the past. “People are paying attention to it now,” says Rodriguez. Through their work and an international certification program called The Code, which brings tourism operators into the fight to prevent the use of children in sex tourism, society in general is more aware of prostitution, he says. Efforts like these are particularly important as countries become hosts to big events like the Summit of the Americas, or as crises occur.  An increased demand for prostitution increases human sex trafficking rings, says Cannoy-Smith. She and a co-author have researched the impact of UN peacekeeping forces in Kosovo, Haiti, and Sierra Leone on trafficking. “When the UN intervenes in civil conflicts, the peacekeepers themselves have often been linked to running and patronizing trafficking rings,” Smith-Cannoy says. “Again, I think that poverty, desperation, the specter of large profits, and relaxed cultural attitudes make these dynamics possible.”

You May Be Able to Actually Make Yourself Smarter—All It Takes Is Practice

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New research shows that, with simple brain exercises, you may be able to actually increase your intelligence—something scientists previously thought impossible. The proof is far from concrete yet, but quite a bit of new evidence suggests that your IQ may be more fluid than originally thought. A study done in 2008 tested children using a "Dual N-Back" game, in which you had to remember longer and longer sequences of things as the game continues, much like Simon (for you 80s kids out there). The researchers found that this game actually targets a fluid part of the brain: . . .the deceptively simple game, it turns out, targets the most elemental of cognitive skills: "working" memory. What long-term memory is to crystallized intelligence, working memory is to fluid intelligence. Working memory is more than just the ability to remember a telephone number long enough to dial it; it's the capacity to manipulate the information you're holding in your head—to add or subtract those numbers, place them in reverse order or sort them from high to low. Understanding a metaphor or an analogy is equally dependent on working memory; you can't follow even a simple statement like "See Jane run" if you can't put together how "see" and "Jane" connect with "run." Without it, you can't make sense of anything. In following studies, the researchers found that over time, children of all intelligence levels showed gains in cognitive abilities due to this "fluid" intelligence, and that these gains lasted three months after training stopped. Their theory is that your IQ, while partially genetic, is not unlike the muscles in your body—if you train it, and keep up that training over time, you can strengthen it. You can play a version of the Dual N-Back game for free, and while there's still a lot of research to be done on this subject, they say you only need 15 to 25 minutes a day, five days a week to see improvements. Hit the link to read the full story over at the New York Times. And, while they won't all necessarily increase your IQ, check out our top 10 other ways to train, exercise, and better your brain.

Blindness partially reversed in mice

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A major study demonstrated that the therapy could restore limited sight to mice born with night blindness, providing the first concrete signs that transplanting nerve cells into the eye can bestow moderate levels of vision. Although the treatment is a long way from being trialled on humans, the "landmark" study offers hope to hundreds of thousands of people suffering from eye conditions like macular degeneration, which affects 15 per cent of over-75s and is the most common form of blindness. While similar treatments involving stem cells have reached the more advanced stage of human trials, the new approach is the first to successfully restore sight using nerve cells which are sensitive to light. Researchers from University College London injected 200,000 immature versions of cells known as rod-photoreceptors, taken from the eyes of newborn healthy mice, into mice with a genetic condition that made them blind in the dark. Some of the cells developed nerve connections which enabled the mice to navigate their way through a maze in low light.

Research reveals 10 subtypes of breast cancers

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An international research team is reporting on the largest effort to date to tease out the characteristics of breast cancer tumours. The work, led by scientists at the B.C. Cancer Agency in Vancouver and Cambridge University in Britain, has found there are at least 10 subtypes of breast cancers. Up till now medicine has recognized about five subtypes of the disease. Studying the variation in tumours is important, because it helps researchers figure out why some women respond to existing breast cancer therapies while others do not. Senior author Dr. Samuel Aparicio of the B.C. Cancer Agency says the work also highlights types of breast cancers for which new treatments must be developed. The study is being published in the journal Nature.

President Barack Obama’s 2012 Drug Control Strategy report

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The first thing you should know about President Barack Obama’s 2012 Drug Control Strategy report is that it begins and ends with the declaration that the war on drugs is working and will continue apace.  Obama administration policies have “yielded significant results,” according to the President’s introductory letter, which concludes by saying, “While difficult budget decisions must be made at all levels of government, we must ensure continued support for policies and programs that reduce drug use and its enormous costs to American society.” The report ends with a familiar refrain: “Legalization of drugs will not be considered in this approach. Making drugs more available and more accessible will not reduce drug use and its adverse consequences for public health and safety. We will continue to educate young people and all Americans about the science on the harmful health effects of marijuana use.” The pages in between those two statements contain a broad outline for increased drug enforcement, mandatory rehabilitation programs for people who don’t need or want them, and the return of melodramatic Reefer Madness-style agitprop aimed at teenagers. The worst policy plans contained in the report are outlined after the jump.  - The report implicitly blames the debate over drug reform—one Obama recently told Univision he’s more than willing to hear—for increased use of drugs by teens: One possible influence on this observed trend in drug use and perception of risk is the decreased exposure of youth to prevention messages and the presence of messages and policies that downplay the consequences of drug use. While the Administration supports ongoing research into determining what components of the marijuana plant can be used as medicine, to date, neither the FDA nor the Institute of Medicine has found the marijuana plant itself to meet the modern standard for safe or effective medicine for any condition. The Administration also recognizes that legalizing marijuana would not provide the answer to any of the health, social, youth education, criminal justice, and community quality of life challenges associated with drug use. - The report encourages carte blanche workplace drug testing, on the grounds that it will curtail productivity losses associated with drug use and improve users’ lives. It also describes the Obama administration’s attempt to develop on oral test for workplace drug testing: In addition to the youth programs mentioned previously, as our young people enter the workplace and others remain engaged in workforce, it is important to ensure a drug-free workplace. The consequences of illicit drug use in America’s workforce include job-related accidents and injuries, absenteeism, health care costs, and lost productivity. Workplace programs that provide clear policies regarding drug use; offer prevention and education opportunities for employers and supervisors; conduct drug testing to detect and deter use; and support referral and treatment for those who have substance use disorders can play a large role in reducing the demand for drugs throughout our Nation and in helping drug users get into treatment. These programs provide employees with the opportunity to self-identify and get help. Often, such programs give employees an opportunity to return to the same job, or a similar job in the same industry, thereby creating an incentive to succeed in their recovery and resume a fulfilling career. Consequently, drug-free workplace programs are beneficial for our labor force, employers, families, and communities in general. In 2011, the Administration committed to funding for the scientific determination for oral fluids testing as a complement to urine testing.  HHS published a Federal Register notice requesting public comment on the scientific basis for oral fluid testing . HHS is moving forward to set standards for oral fluid testing that will be published in the future for public comment before they can be finalized in the Mandatory Guidelines for Drug Workplace Testing.  These Guidelines will also be available for state and local jurisdictions to apply as appropriate for the prosecution of drugged driving violations, and to encourage the drug testing industry to develop accurate point-of-collection oral fluid testing devices. - The report contains a request to Congress for $20 million to Revamp and Reenergize the National Youth Anti-Drug Media Campaign, which was defunded by Congress last year because it doesn’t work: Since 2005, there has been a significant public investment in developing the widely-recognized “Above the Influence” (ATI) brand, a campaign that has been found by independent scientific analyses to be effective, relevant to youth, and instrumental to drug prevention efforts in communities across the country. Unfortunately, despite evidence of its effectiveness, Congress appropriated no funding for the Media Campaign in Fiscal Year (FY) 2012, and the campaign is now operating on a minimal budget composed of its unobligated balances as the Youth Drug Prevention Media Program. The report also calls for a nationwide zero tolerance policy for "drugged driving," which would mean all drivers would be subjected to laws that currently affect only commercial drivers: The Administration encourages states to pursue enhanced legal responses, such as per se (or “zero tolerance”) laws. Seventeen states already have per se statutes, and additional states should consider adopting these standards. These same standards have been applied to 12 million commercial drivers in the United States for the past two decades. The Administration has developed educational packets for states, providing them with information on the dangers of drugged driving and why per se laws are beneficial. - The report also says that “Several options are being considered to further reduce methamphetamine production including prescription-only status for pseudoephedrine/ephedrine products.” The Marijuana Policy Project’s Rob Kampia has called the report “appalling,” adding, “The drug czar is trying to resurrect those stupid TV ads, like the one where a teenager gets his fist stuck in his mouth. The budget intentionally undercounts the federal government's expenditures on incarcerating drug offenders, who comprise more than half of the federal prison population. And the budget dangerously proposes a massive escalation in using the military to fight drugs domestically. Congress should just ignore this budget and start from scratch. Specifically, Congress should not provide the Obama administration with any money to go after nonviolent marijuana users, growers, or distributors." Law Enforcement Against Prohibition also attacked the report. "President Obama keeps saying he is open to a discussion but he never seems willing to actually have that discussion,” said LEAP Director Neil Franklin said in a press release. “Polls show that three out of four U.S. voters think the 'war on drugs' is a failure and a majority now support marijuana legalization. The time for real change is now, but at the Summit of the Americas President Obama announced more than $130 million in aid to fund the continued effort to arrest drug traffickers in Latin America. This prohibition strategy hasn't worked in the past and it cannot work in the future. Latin American leaders know it, and President Obama must know it. Let's stop the charade and begin to bring drugs under control through legalization." Former ONDCP senior advisor Kevin Sabet, meanwhile, is doing promotion for the report, which he refers to as “Wake Up and Grow Up.” In anticipating criticism of the report, Sabet writes, "The 2012 release is likely to be attacked by those who are waiting for the day the President will make a U-turn and support legalization—but attackers will unfortunately miss the nuance and striking clarity which characterizes this particular document and its connection with the first Strategy." Fun fact: Sabet wrote the first strategy!  More Reason on Obama's drug policies, including investments in police violence, the myth that the president's policies are "compassionate" and Jacob Sullum's must-read feature on how Obama turned out to be just another drug warrior.

The first thing you should know about President Barack Obama’s 2012 Drug Control Strategy report is that it begins and ends with the declaration that the war on drugs is working and will continue apace.  Obama administration policies have “yielded significant results,” according to the President’s introductory letter, which concludes by saying, “While difficult budget decisions must be made at all levels of government, we must ensure continued support for policies and programs that reduce drug use and its enormous costs to American society.” The report ends with a familiar refrain: “Legalization of drugs will not be considered in this approach. Making drugs more available and more accessible will not reduce drug use and its adverse consequences for public health and safety. We will continue to educate young people and all Americans about the science on the harmful health effects of marijuana use.” The pages in between those two statements contain a broad outline for increased drug enforcement, mandatory rehabilitation programs for people who don’t need or want them, and the return of melodramatic Reefer Madness-style agitprop aimed at teenagers. The worst policy plans contained in the report are outlined after the jump.  - The report implicitly blames the debate over drug reform—one Obama recently told Univision he’s more than willing to hear—for increased use of drugs by teens: One possible influence on this observed trend in drug use and perception of risk is the decreased exposure of youth to prevention messages and the presence of messages and policies that downplay the consequences of drug use. While the Administration supports ongoing research into determining what components of the marijuana plant can be used as medicine, to date, neither the FDA nor the Institute of Medicine has found the marijuana plant itself to meet the modern standard for safe or effective medicine for any condition. The Administration also recognizes that legalizing marijuana would not provide the answer to any of the health, social, youth education, criminal justice, and community quality of life challenges associated with drug use. - The report encourages carte blanche workplace drug testing, on the grounds that it will curtail productivity losses associated with drug use and improve users’ lives. It also describes the Obama administration’s attempt to develop on oral test for workplace drug testing: In addition to the youth programs mentioned previously, as our young people enter the workplace and others remain engaged in workforce, it is important to ensure a drug-free workplace. The consequences of illicit drug use in America’s workforce include job-related accidents and injuries, absenteeism, health care costs, and lost productivity. Workplace programs that provide clear policies regarding drug use; offer prevention and education opportunities for employers and supervisors; conduct drug testing to detect and deter use; and support referral and treatment for those who have substance use disorders can play a large role in reducing the demand for drugs throughout our Nation and in helping drug users get into treatment. These programs provide employees with the opportunity to self-identify and get help. Often, such programs give employees an opportunity to return to the same job, or a similar job in the same industry, thereby creating an incentive to succeed in their recovery and resume a fulfilling career. Consequently, drug-free workplace programs are beneficial for our labor force, employers, families, and communities in general. In 2011, the Administration committed to funding for the scientific determination for oral fluids testing as a complement to urine testing.  HHS published a Federal Register notice requesting public comment on the scientific basis for oral fluid testing . HHS is moving forward to set standards for oral fluid testing that will be published in the future for public comment before they can be finalized in the Mandatory Guidelines for Drug Workplace Testing.  These Guidelines will also be available for state and local jurisdictions to apply as appropriate for the prosecution of drugged driving violations, and to encourage the drug testing industry to develop accurate point-of-collection oral fluid testing devices. - The report contains a request to Congress for $20 million to Revamp and Reenergize the National Youth Anti-Drug Media Campaign, which was defunded by Congress last year because it doesn’t work: Since 2005, there has been a significant public investment in developing the widely-recognized “Above the Influence” (ATI) brand, a campaign that has been found by independent scientific analyses to be effective, relevant to youth, and instrumental to drug prevention efforts in communities across the country. Unfortunately, despite evidence of its effectiveness, Congress appropriated no funding for the Media Campaign in Fiscal Year (FY) 2012, and the campaign is now operating on a minimal budget composed of its unobligated balances as the Youth Drug Prevention Media Program. The report also calls for a nationwide zero tolerance policy for "drugged driving," which would mean all drivers would be subjected to laws that currently affect only commercial drivers: The Administration encourages states to pursue enhanced legal responses, such as per se (or “zero tolerance”) laws. Seventeen states already have per se statutes, and additional states should consider adopting these standards. These same standards have been applied to 12 million commercial drivers in the United States for the past two decades. The Administration has developed educational packets for states, providing them with information on the dangers of drugged driving and why per se laws are beneficial. - The report also says that “Several options are being considered to further reduce methamphetamine production including prescription-only status for pseudoephedrine/ephedrine products.” The Marijuana Policy Project’s Rob Kampia has called the report “appalling,” adding, “The drug czar is trying to resurrect those stupid TV ads, like the one where a teenager gets his fist stuck in his mouth. The budget intentionally undercounts the federal government's expenditures on incarcerating drug offenders, who comprise more than half of the federal prison population. And the budget dangerously proposes a massive escalation in using the military to fight drugs domestically. Congress should just ignore this budget and start from scratch. Specifically, Congress should not provide the Obama administration with any money to go after nonviolent marijuana users, growers, or distributors." Law Enforcement Against Prohibition also attacked the report. "President Obama keeps saying he is open to a discussion but he never seems willing to actually have that discussion,” said LEAP Director Neil Franklin said in a press release. “Polls show that three out of four U.S. voters think the 'war on drugs' is a failure and a majority now support marijuana legalization. The time for real change is now, but at the Summit of the Americas President Obama announced more than $130 million in aid to fund the continued effort to arrest drug traffickers in Latin America. This prohibition strategy hasn't worked in the past and it cannot work in the future. Latin American leaders know it, and President Obama must know it. Let's stop the charade and begin to bring drugs under control through legalization." Former ONDCP senior advisor Kevin Sabet, meanwhile, is doing promotion for the report, which he refers to as “Wake Up and Grow Up.” In anticipating criticism of the report, Sabet writes, "The 2012 release is likely to be attacked by those who are waiting for the day the President will make a U-turn and support legalization—but attackers will unfortunately miss the nuance and striking clarity which characterizes this particular document and its connection with the first Strategy." Fun fact: Sabet wrote the first strategy!  More Reason on Obama's drug policies, including investments in police violence, the myth that the president's policies are "compassionate" and Jacob Sullum's must-read feature on how Obama turned out to be just another drug warrior.

Man who doctors wrote-off as dead leads normal life

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A man left in a coma by a horrific car crash is now living a normal life, despite his family being told by doctors that they intended to switch off his life-support machine when he was in hospital. Steven Thorpe, from Kenilworth in Warwickshire, was 17 at the time of the accident and only survived because his parents insisted on getting a second opinion.

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